[3] Creve Coeur borders and shares a ZIP code (63141) with the neighboring city of Town and Country.

The name crève cœur (French pronunciation: [krɛv kœʁ], "heartbreak") is said to derive from Creve Coeur Lake.

[6] Written accounts and archaeological finds show that Native Americans inhabited the Creve Coeur area from 9500 BC to 1800 AD.

When the area was acquired by the United States through the Louisiana Purchase in 1803, the Lewis and Clark Expedition came through Creve Coeur.

During the American Civil War, men from the area served on both sides of the conflict, but most residents were southern sympathizers.

Although cabins more than 200 years old (including two still in Conway Park) are in the community, it grew primarily as a stopping point along Olive Boulevard (now Route 340) between University City and Creve Coeur Lake.

According to the United States Census Bureau, the city has a total area of 10.27 square miles (26.60 km2), all land.

[9] The City of Creve Coeur's Charter was adopted in 1976, providing for a council-city administrator form of government.

The 2020 United States census[14][failed verification] counted 18,834 people, 8,230 households, and 4,817 families in Creve Coeur.

Pattonville School District covers a northeast portion of the city limits of Creve Coeur.

Missouri Baptist University is located within the city of Creve Coeur along with Covenant Theological Seminary.

Creve Coeur is recognized as a key node for technology, life and bio sciences, and medical services in the St. Louis region.

It is home to Bayer, the Donald Danforth Plant Science Center & the Bio Research and Development Growth Park, all located in the 39 North Agtech Innovation District.

[22] The state of Missouri and the city of Creve Coeur had offered Isle of Capri more than $4.2 million in tax incentives.

Five of the top 15 largest information technology consulting firms in St. Louis are located in Creve Coeur, including the top two:[30] TEKsystems, Computer Sciences, Daugherty Business Solutions, Volt Workforce Solutions, Bradford & Galt, Envision, and iBridge Solutions Two of the top 10 largest life science research organizations in St. Louis are located in Creve Coeur:[33] Bayer and Donald Danforth Plant Science Center The American Association of Orthodontists has its headquarters in the city.

[34] The City of Creve Coeur maintains six parks with amenities including playgrounds, walking trails, tennis courts, and athletic fields.

[35] The City of Creve Coeur also operates the Dielmann Recreation Complex, which includes a 9-hole golf course and ice arena.