In the episode "Paradise", William Mapother and Robyn Lively guest-starred as Ian and Abby Corbin, a married couple who go on vacation, only to be held captive by Floyd Hansen.

Guillermo Díaz guest-starred as gang member and suspect Playboy, and Doug Jones appeared as fight club captain Beanie.

In the episode "Bloodline", Andrew Divoff and Cynthia Gibb guest-starred as Lewis and Kathy "Sylvia" Gray, a gypsy couple who abducted young girls for their son to marry by the time he comes of age.

In the episode "Cold Comfort", Vondie Curtis-Hall guest-starred as Stanley Usher, a self-proclaimed psychic of whom David Rossi is skeptical, and Cybill Shepherd as Leona Gless.

In the episode "Pleasure Is My Business", Brianna Brown guest starred as Megan Kane, a call girl who fatally poisons her clients.

In the episode "Omnivore", C. Thomas Howell guest-starred as George Foyet, the only person who survived a string of killings committed by a killer known as "The Boston Reaper".

In the episode "The Big Wheel", Alex O'Loughlin guest-starred as Vincent Rowlings, a repentant serial killer who suffers from uncontrollable homicidal urges.

In the two-part season finale "To Hell and Back", Garret Dillahunt guest-starred as Mason Turner, whose developmentally disabled brother and partner in crime, Lucas, abducts a teenage girl and holds her captive at a barn in Canada.