After studying in Tabio, he attended the Major Seminary of Bogotá, alongside his future successor as archbishop of the same, Luis Concha Córdoba.

He received his episcopal consecration on the following May 3 from Archbishop Paolo Giobbe, with Bishops José Ignacio López Umana and Luis Adriano Díaz serving as co-consecrators, in the Cathedral of Bogotá.

In 1951, he formally asked the Ministry of Education to remove José Rodriguez's paintings, which contained nude subjects, from the National Museum.

[1] Luque also played a prominent role in the civil and political crisis that affected his country from 1949 to 1958, and participated in the 1958 papal conclave that selected Pope John XXIII.

[3] To the military junta that replaced Rojas, he also threatened to withdraw the Church's support if it did not turn over power in free elections.