Cristóbal Diatristán de Acuña, SJ (1597 – c. 1676) was a Spanish Jesuit missionary and explorer.
He was admitted a Jesuit in 1612, and afterwards sent on mission work to Chile and Peru, where he became rector of the college of Cuenca.
In 1639 he accompanied Pedro Teixeira in his second exploration of the Amazon, in order to take scientific observations, and draw up a report for the Spanish government.
The journey lasted ten months; and on the explorer's arrival in Belém, Acuña prepared his narrative, while awaiting a ship for Europe.
After occupying the positions of procurator of the Jesuits at Rome and censor (calificador) of the Spanish Inquisition at Madrid, Acuña returned to South America, where he died, probably soon after 1675.