Don Cristóbal de Guzmán Cecetzin (or Cecepaticatzin) was a colonial Nahua noble from Santa María Cuepopan in San Juan Tenochtitlan.

A son of the ruler don Diego Huanitzin, don Cristóbal first served as alcalde in 1556 before becoming Tenochtitlan's next-to-last tlatoani and third governor in 1557, titles he held until his death in 1562.

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