On 21 July 1521 he sailed from the mouth of Rio Tejo (Tagus) to Brazil, founded an outpost in Itamaracá, Pernambuco, one of the most popular anchorages on the Brazilian coast, where there was plenty of Brazil wood (Caesalpinia echinata) and had frequent contacts between Natives and Europeans, before going south to Río de la Plata and entering the Parana River for about 23 leagues (around 140 km) to near the present city of Rosario for the first time.
[2] Finally, in 1526, he was appointed, by King João III, as Governor of all Parts of Brazil, replacing Pero Capico in Pernambuco, and returned again in command of a ship and five caravels, having countless battles with French pirates.
Upon returning to Portugal, he made an offer to the King, in which Jacques would take one thousand colonists, at his own expense, to begin the permanent occupation of the new lands in Brazil, but nothing came of the proposal.
In a letter from Frei Vicente do Salvador, it is recorded that Christóvão Jacques found an island (already controlled by the French), on the lower river course of the Paraguaçu two ships that traded with the Indians, and were properly sunk.
At the site there would be a town later named village of Nossa Senhora do Rosário da Cachoeira, in the early 17th century allotment of Gaspar Dias Adorno, ideal for penetration of the captaincy.