Before her television career, she worked for ten years as editor-in-chief of the Spanish-language version of Cosmopolitan magazine distributed throughout Latin America.

[1] In 1960, following the Cuban Revolution, Saralegui and her family fled to Miami, Florida, United States, and settled on Key Biscayne.

This sometimes put her at odds with Gurley Brown, whose approach to the English-language magazine was more sexually forward, while Saralegui recognized that there were still many facets of "liberation" Latin women still had not attained.

)[3] Prominent guests included Shakira, Paulina Rubio, Don Francisco, the former members of Menudo, Fernando Colunga, Selena, Lucero, Celia Cruz, Camilo Sesto, Thalía, Olga Tañón, Isabel Pantoja, Julio Iglesias, Jaci Velasquez, Alejandro Fernández, Enrique Iglesias, Pitbull, Sussan Taunton, Jorge Ramos, Gloria Estefan and her husband Emilio Estefan, Jr., Gloria Trevi, Chayanne, Sebastian Rulli, Xuxa, Ricky Martin, RBD, Niurka, Noelia, Anaís, George Lopez, Jennifer Lopez, Adela Noriega, Grecia Colmenares, Alexandra Cheron, Amelia Vega, Angélica Vale, Angélica María, and Susana Gonzalez.

[6][7] The song Somos El Mundo premiered during Saralegui's show, with an appeal to help the Haiti relief effort.

It was discussed that she might continue as a collaborator, for special programs and interviews, and that a new Cristina show would debut in March, 2011, but this did not happen.

[9] The Spanish-language Network Azteca América presented a one-hour special, "Cristina Breaks the Silence" where, for the first time since her retirement from Univision, Saralegui was interviewed on television.

[11] The program debuted on Telemundo on May 31 of that year, hosting a one-hour special retrospective featuring the stars of the just-completed telenovela La Reina del Sur.