She is best known for her role as Angela Petrelli on the hit NBC science fiction drama Heroes.

[citation needed] She was a regular on the short-lived television series Ferris Bueller which was a TV remake of the famous film Ferris Bueller's Day Off which she co-starred in with a then-unknown Jennifer Aniston.

She also had major recurring roles on Picket Fences as Lydia Brock, as Barbara Norton on Grace Under Fire, and on Providence as Cynthia Blake.

Rose has had guest roles in various shows, including 7th Heaven, Life Goes On, Friends, Days of Our Lives, Passions, Party of Five, The Wonder Years, Matlock, Malcolm in the Middle, Ally McBeal, Murder, She Wrote, Boston Legal, Diagnosis: Murder, Nash Bridges, CSI: Crime Scene Investigation, NCIS, NCIS: Los Angeles,[1] The Practice, L.A. Law, Chicago Hope, Crossing Jordan, ER, St.

Elsewhere, Star Trek: The Next Generation, Gilmore Girls, Kate & Allie, Murphy Brown, Newhart, Growing Pains, How I Met Your Mother, Sabrina, the Teenage Witch, Clueless, Dharma and Greg, Life with Bonnie, The Nanny, The Jamie Foxx Show, The King of Queens, Two and a Half Men, Big Love, The Mentalist, Six Feet Under, and Charmedand How to Get away with Murder (she played a judge in one episode) From 2006 to 2010, Rose played Angela Petrelli on the NBC series Heroes.