In 1884 Crosby reported a population of 50, a school, a Baptist church, and a general store.

The Crosby Independent School District was chartered by a special session on Friday June 27, 1919 of the 36th 2nd Called Session of the Texas Legislature under the leadership of Governor William P. Hobby, Lieutenant Governor Willard Arnold Johnson, and Speaker of the House Robert Ewing Thomason.

[5] According to Texas Education Agency Snapshot 2016 District Detail, Crosby ISD served 5,666 students.

In March 2021, Mrs. Paula Patterson was named the lone finalist in the district's superintendent search.

[10] In October 2018 the district laid off 34 contracted employees, including teachers, due to financial issues.

By then, the administration proposed a four day school week, which would make the district the first in the county to adopt such a schedule.

[15] There were some parents in the district who argued that such a move would increase their burden in seeking childcare during the week.

One of the most recent additions is the memorial garden on the bus porch created as a service project by LOTC (JROTC).