Cross Keys House is a historic plantation house located at Cross Keys, Union County, South Carolina.

It was built about 1812–1814, and is a two-story, five-bay, brick Georgian Colonial style dwelling.

It features a gabled roof with identical pairs of end chimneys, a massive raised first-story portico, and date stones carved with the date of the house's completion (1814), original owner's initials (B.B.

[2][3] It was added to the National Register of Historic Places in 1971.

This article about a property in Union County, South Carolina on the National Register of Historic Places is a stub.