The festivals benefit the Crossroads Centre founded by Eric Clapton, a drug treatment center in Antigua.

It was held under a different title which was Eric Clapton & Friends In Concert: A Benefit For The Crossroads Centre At Antigua.

Some performers at the 1999 Concert were David Sanborn, Sheryl Crow, Bob Dylan and Mary J Blige.

Some performers at the Crossroads Guitar Festival such as Jeff Beck, Pat Metheny, Neal Schon, and Styx were not included on the DVD.

[4] Performers included:[4][5][6] The 2019 festival was held on September 20–21 at the American Airlines Center in Dallas, Texas.

[7] MC: Bill Murray Performers included: Outdoor Venue: Among the Village Stage performers will be surprise main stage artists, along with special guest guitarists such as Eric Johnson, Joe Robinson, Andy Timmons, Paul Reed Smith, Boscoe France, Bryan Ewald, Ryan McGarvey and Peterson Brothers, with others.

However, Guy canceled his performance on September 19th because of a medical issue and Robbie Robertson died on August 9, the month prior to the festival.