[15] The identified prey items included 16 lizards, six small mammals, and three birds, such as Deer Mouse (Peromyscus maniculatus), Wood Rat (Neotoma albigula), and various Sceloporus species.

Ontogenetic shifts in prey preference have been noted, with a transition from primarily consuming lizards to mammals as the snakes grow.

However, one observation noted the snake consuming Ord's Kangaroo Rat (Dipodomys ordii), adding a new species to the known prey items for this rattlesnake.

[19] This species predominantly inhabits high, cold deserts characterized by sagebrush (Artemisia (plant)) and an abundance of rock outcrops and exposed canyon walls.

[20] Greasewood (Sarcobatus vermiculatus), juniper (Juniperus scopulorum), and other woody plants are also present, sometimes even dominating certain areas.

[20] After emerging from hibernation in April and May, the snakes stay near the den entrance for 2 to 3 weeks before moving to "shedding habitats," characterized by large flat rocks that assist in molting.

Males and non-gravid females, on the other hand, have some of the longest migrations and largest activity ranges reported for rattlesnakes.

[20] This species possesses the most toxic venom of the C. oreganus / C. viridis group, although apparently considerable variability exists among local populations.

[21] It is characterized by the presence of a presynaptic neurotoxin, referred to as concolor toxin, the amount of which varies in individual snakes.

[14] It contains a potent presynaptic phospholipase A2-based neurotoxin, known as "concolor toxin," which blocks the release of acetylcholine from nerve axon terminals, resulting in rapid prey immobilization.

[23][26] Human envenomations by C. concolor are rare, likely due to the snake's remote habitat and generally mild disposition.