In 2010, Seasons After scored a top twenty hit on Billboard's Mainstream Rock Songs with their version of the track,[6] after it was included on their 2010 album Through Tomorrow.

Eight years later, Marilyn Manson released their cover version as a single after it was featured in a promotional trailer for the television series Titans.

Director Joel Schumacher asked English singer-songwriter Gerard McMahon to write a theme for his 1987 film The Lost Boys.

[8] Despite appearing on the soundtrack to The Lost Boys, the song's lyrics do not specifically reference vampires, as it was composed before McMahon had seen any footage from the film.

It was remixed by The Lost Brothers and issued as a single in 2003 under the title "Cry Little Sister (I Need U Now)", crediting McMahon by the name of his current band, G Tom Mac.

A video for "Cry Little Sister (Club Cave Mix)" was produced by DJ Lee and G Tom Mac, and included as a bonus feature on the Lost Boys: The Tribe DVD in 2008.

[14] In 2011, American rock band The Anix released their version of the song as the second single as part of their second full-length studio album Sleepwalker.

[18] Despite the delay, Manson's version also appeared in another comic book adaption when it was played in the promo for the 2018 DC TV series Titans.