As it was located in the central arid area, it attracted a lot of people interested in the silver mines around Cuencamé.

A famous monk, Francisco Santos, was in control of the Saint Anthony monastery in Cuencamé.

Carlos Michaud, who founded the village of Pedriceña, captain of Pedriza in the Colonial period, also resided here.

During the Mexican revolution period, Calixto Contreras (1867–1918) and Severino Ceniceros (1880–1937) were notable people from Cuencamé.

[2] It is “a wide valley around by beautiful mountains according to words of father Jeronimo Ramirez Jesuit priest who came to this place in August 1594.

A letter from Rodrigo de Paz explains that Captain Martin de Zapata arrived to Cuencame and that before him were presented the caciques from Manganapa, Salina and Rio of Nazas they were the ones who took the name of the Captain and they received lands for their settlement.

The mine of Terneras caused the installation of the plant property of American Smelting and Refining Company, which exhausted its silver veins.

The Velardeña valley and its rich mineral mines serve as the town limit for the village of the same name.

In the northeastern part of the town, a little beyond the San Lorenzo mountains, up the steep and rugged Sierra de Guadalupe that runs parallel to the Sierra de Jimulco, in the Municipality of Simon Bolivar and the state of Coahuila, the two mountain ranges of Guadalupe and Jimulco form a more or less wide canyon where the Aguanaval river and the Central railroad run.

The surrounding area of these mountains is arid and the Cretaceous formations of the plates and layers of the ground are visible.

The Cuencamé stream runs into the Nazas River at the point named Rancho de Fernández.