[1] The reserve may be reached by boat from Manaus, the capital of Amazonas, 918 kilometres (570 mi) distant.

[4] The Cujubim Sustainable Development Reserve is part of the Central Amazon Biodiversity Corridor, along with other conservation units on either side of the Solimões.

The reserve hosts populations of threatened or endangered species such as the giant otter (Pteronura brasiliensis), South American tapir (Tapirus terrestris), jaguar (Panthera onca), cougar (Puma concolor) and Amazonian manatee (Trichechus inunguis).

[1] The reserve is in a very isolated area, with high levels of poverty and low human development indices.

[8] A survey before the reserve was created showed that about 56% of residents were illiterate, while the remainder had no more than 4th grade elementary education.

The main sources of income are marketing salmorado fish, particularly surubi, logging and capture of turtles.

[1] The residents have traditionally depended on "regatões" (middlemen) who purchase their products and bring supplies from the city, often at unfair prices.

[8] Credit is being supplied so the residents can break free of debt to the "regatões" and market their products directly.

[10] As an alternative to logging the agencies involved in managing the reserve are encouraging extraction of resins, copaiba and andiroba oils and rubber.