It is a 38,500 square-foot space at 139 West Main Street, and is part of the city's Scioto Mile tourist district.

It offers community oriented arts classes at a variety of levels, and is also utilized as an events space.

This brick Italianate arsenal building housed weapons and horses during the American Civil War.

It was transformed into an arts center starting in 1976, with the help of a $1.4 million grant from the US Department of Commerce, with the official opening on June 11, 1978.

The building was named for Priscilla Tyson, the longest-serving female councilmember on the Columbus City Council, in 2023.