Leonora Navarro (Diana Bracho), a young woman from San Cristóbal de las Casas, Chiapas, works in Mexico City and lives at the home of her godmother, Esperanza (Carmen Montejo).

One day, a car crashes into the windows of the office where Leonora works and she tries to help the driver, a wealthy businessman, owner of some laboratories, named Carlos Larios (Raúl Meraz), who dies in the accident.

Using tricks, Alejandro takes her to San Miguel Allende, to a clinic run by a foreign doctor of dubious reputation, where she is cared for by the sinister nurse Rosalía (Lilia Aragón).

At the same time, Catalina Creel will go on to commit several crimes so as to ensure that no one discovers her two greatest secrets: That she has not lost her eye and that Alejandro's son, whom they call "Little Édgar", is not Vilma's.

The central character in Cuna de lobos is Leonora Navarro, played by Diana Bracho, who portrays the victim of the "wolves", only to "become" a "she-wolf" herself to seek revenge.

The main antagonist is matriarch Catalina Creel, played by actress María Rubio, a villain in the grand dramatic tradition of Dynasty's Alexis Carrington, Dallas' J. R. Ewing, or Knots Landing's Abby Cunningham.

Catalina's unnatural devotion to her only son caused her to conceal a healthy eye behind the lie of blindness, commit a series of murders, beginning with that of her own husband, Carlos, (his mistake was realizing how evil she truly was) and to participate in the abduction of a child to ensure an inheritance.

Cuna de lobos was so popular in its native country that, on the night of the final broadcast, the streets of Mexico City (infamously choked with traffic) were deserted, as the locals were in their homes glued to their TV screens.