In 1999, after the agreement expired, the league transferred its offices and most of its games to the PhilSports Arena, the PBA's home from 1985 to 1992.

The Pasay Voyagers of the Maharlika Pilipinas Basketball League have played all of their home games in the Astrodome since the team's establishment in the 2018–19 MPBL season.

Aside from hosting PBA games, it also held several collegiate leagues such as the UAAP, NCAA, NAASCU, WNCAA and the UCAA.

It also hosted the Philippine Basketball League during the mid-1990s and during the 2005 PBL Unity Cup finals between the champion Welcoat Paintmasters and the Montana Jewels.

Since 1993, the coliseum has held 16 professional boxing programs,[6] most notably Rolando Pascua's win over Dodie Boy Peñalosa and its undercard.

On July 19, 1997, Rage Against the Machine performed live at Cuneta Astrodome as part of their Evil Empire Tour Asian leg.

A fire broke out at the venue on November 10, 2021, when medical workers were preparing for the inoculation drive for that day.

[8] In 2006, the Astrodome was refurbished with new seats and a new flooring was installed for the basketball games as the venue had shown tremendous signs of deterioration over the past few years.

It was the biggest renovation that occurred at the Astrodome, as past events resulted in minor refurbishment of the arena.