Cuomo Prime Time was an American news analysis show aired on CNN from June 4, 2018 to November 29, 2021.

Hosted by Chris Cuomo, the series featured analysis and debates on current news topics, as well as in-depth interviews with notable figures.

[6] A format established by Cuomo as one of two main co-hosts of the weekday edition of CNN's New Day, a three-hour morning news show, consists of an in-depth interview with a leading newsmaker (usually a senior public figure such as a politician, legal advocate or a celebrity in a public campaign), and it became an important part of Cuomo Prime Time during the show's two trial runs.

[7] CNN's audience share has grown in recent years, but still lags behind that of Fox News and MSNBC during prime time.

[9] However, during its January trial run, Cuomo Prime Time tied with CNN's highest-rated show, Anderson Cooper 360°, among television viewers in the important 25-54 age ranges.

[8] Cuomo Prime Time was scheduled to directly compete with Fox News' Hannity and MSNBC's The Rachel Maddow Show, which both consist of partisan political commentary from their respective presenters, in contrast to the analytical approach of CNN, in which a wide range of experts and political veterans with differing opinions are interviewed in large studio-based panel discussions.

Cuomo says that his interviews will feature newsmakers whom he will challenge if their statements are non-factual, and that his new show will encourage "debating with decency".

[12] Cuomo said that his new show would "not be tethered to the TV studio" and that he would travel more frequently for live broadcasts to the scenes of big breaking news.

[17] On December 1, 2021, CNN received additional allegations that Chris had engaged in sexual misconduct involving an anonymous former colleague, represented by attorney Debra Katz.