The film's success led it to receiving direct-to-video sequels, a television series (which aired three specials during its run) as well as a video game.

In the film, George is asked to take part in a special mission to space, but a mishap during the journey lands him back to the jungle where he originally came from.

The film features George and Ted traveling to Cousin Ginny's farm for a relaxing vacation, but their fun is cut short when a herd of animals escape and run loose.

George and Ted go on vacation to the town of Coddington with a small house owned by a treasure lover, Captain Elmer to find ancient treasure buried somewhere in his land or the beaches along with a baby seal making his way into the adventure with an endangered seal mom.

The series explores themes of learning, forgiveness and playful curiosity, and follows George, who is a sweet but trouble making African monkey.