Vehicles include the TF-22 Transfighter stealth jet, a nanotech virus cleaner, "Charlie" the remotely operated decontamination robot, and the Cyberia weapon itself.

The only other modes of attack during the walking portions of the game consist of traps that must be set to outsmart an enemy, which goes hand-in-hand with the occasional demand for stealth.

The "Charlie" robot adds a new form of attack: a weapon which kills all enemies on the screen at the cost of a moderate amount of the machine's energy.

Zak can use his suit's BLADES (Bi-optic Low Amplitude Displayed Energy System) to scan the current puzzle in several ways for help in completing it.

William Devlin, the leader of the FWA, receives word that a devastating weapon is being produced in a secret base in Siberia, referred to as the Cyberia Complex.

Already becoming aware of Cyberia's secret operations, the Cartel seizes control of the Complex with the same goal as the FWA which is to discover the nature of the super weapon being produced by a third party.

"[9] Similarly, IGN stated that the "use of multiple camera angles, eerie soundtrack, detailed light-sourcing, and short, effective cut-sequences really pulls the player into the game.

"[3] Radion Automatic of Sega Saturn Magazine likewise commented that "the graphics remain stylistically constant pretty much throughout (apart from the ropey anti-aircraft concept), displaying solid-looking rendered characters and backgrounds in a cinematic enough fashion to carry the atmosphere.

[10][11] A reviewer for Next Generation praised the rendered graphics, soundtrack, and "absorbing" storyline, and said even with the very limited interactivity, "Cyberia keeps itself above the competition by mixing sequences with puzzles and plot devices that keep the gamer drawn into the story".

[11] One reviewer for Next Generation found the main problem to be that Cyberia does not allow the player to explore and "[create] your own story",[6][7] while another simply stated "it never achieves the level of interactivity that's required to make it a truly great game.

After Zak and the Cyberia weapon crash land back on Earth following the destruction of Devlin's orbital headquarters, they are intercepted by an FWA team led by a Dr. Corbin.

Corbin, under orders from his FWA employers, places Zak in cryo-storage and uses the remains of the Cyberia weapon to create a deadly virus called nano-toxin.

Though the FWA seeks to quell a growing rebel movement with the nano-toxin, the maniacal Corbin intends to use it to kill millions and "reshape the world as we know it."