[9] Cygnus, an advanced maneuvered spacecraft, mates a Pressurized Cargo Module, provided by Orbital's industrial partner Thales Alenia Space, with their GEOStar satellite bus.

[12] The second launch attempt on 14 February 2020 at 20:43:34 UTC was scrubbed due to strong upper winds with less than ninety minutes left in the countdown.

The Saffire-IV experiment was conducted within Cygnus after it departs the station, and prior to deorbit, when it disposed of several tons of trash during reentry into Earth's atmosphere, over the Pacific Ocean, on 29 May 2020.

[14] The Cygnus spacecraft was loaded with 3,377 kilograms (7,445 lb) of pressurized cargo with packaging, broken down as follows:[15] NASA provided the following breakdown of the cargo's hardware for ISS:[15] The new experiments arriving at the orbiting laboratory will challenge and inspire future scientists and explorers, and provide valuable insight for researchers.

Experiments will test new facilities for microscopic viewing and cell culturing, and particle identification will seek to better understand how fire spreads in microgravity and will study how bacteriophages behave in space.

[2] The Cygnus host a NASA combustion experiment inside its pressurized cabin before Northrop Grumman controllers command the spacecraft to a destructive re-entry over the South Pacific Ocean on 29 May 2020.

[3] On 26 May, after unberthing from the ISS and before disposal, the experiment in rocket exhaust driven amplification (REDA) of very low frequency (VLF) radiowaves was conducted.

The BT-4 engine on Cygnus was fired for 60 seconds, while coherent 25.2 kHz VLF radiowaves were transmitted through the rocket exhaust plume from the U.S. Navy NML Transmitter in LaMoure, North Dakota.