About 50, see text Cyphomandra was a formerly accepted genus in the plant family Solanaceae (the nightshades and relative).

It used to contain about 35 species native to the Americas from Mexico southwards to Northern Argentina.

This lineage is one among a group related to part of the traditional subgenus Leptostemonum.

Thus, if it is preferred to retain the taxon, Cyphomandra is probably best considered a section in Solanum subgenus Leptostemonum.

Several other species (e.g. S. cajanumense, S. circinatum, S. sibundoyense) also have fruits that are edible when ripe, and yet others are used as dyestuffs or in folk medicine where they are native.