Both nations have experienced periods of external influence, such as the Ottoman Empire's rule over both territories, which fostered shared cultural and economic exchanges.

However, Cyprus has participated in international discussions related to the Syrian Civil War, advocating for peaceful resolutions and providing humanitarian aid through European and UN-led initiatives.

[11] Cyprus has played a role in international efforts to provide humanitarian assistance to Syrian refugees and has served as a transit point for aid to Syria due to its geographic proximity.

[17] As part of this approach, Cyprus has also sought to engage with the Assad regime,[18] a policy that contrasts with the stance of the European Union, which has largely opposed normalization with the Syrian government.

He added that Syria's unity, territorial integrity, and sovereignty must be upheld, and a peaceful, inclusive, and Syrian-led political transition is demanded according to UN Security Council Resolution 2254.