[9] The Bilateral partnership focuses in areas of common interest, such as peace, security, trade and investment, diversifying European energy sources, and protecting cultural heritage across the island.

[10][11][12] The Cabinet of Israel approach of Cyprus over the recent years, and especially after the Gaza flotilla raid, has boosted Cyprus–Israel relations even further.

[13][14] In 2018, the United States and the Republic of Cyprus signed a Statement of Intent to also strengthen and develop their security relationship.

The agreement encompasses efforts to combat terrorism, enhance maritime security and further promote regional stability in the Eastern Mediterranean.

Prior to his appointment, Ross was a successful banker known for acquiring and restructuring companies and later selling them for a profit once operations have been improved.

Cyprus also signed a Proliferation Security Initiative with the United States on July 25, 2005, which reinforces bilateral counter-terrorism cooperation.

[24][25] The "US remains deeply concerned by Turkey's repeated attempts to conduct drilling operations in the waters off Cyprus...

Subsequently, a Turkish invasion of Cyprus has followed, that resulted in the capture of approximately 40% of the island and a de facto division of its people and land since 1974.

[33] The United States regards the status quo on the Cyprus dispute as "unacceptable" and fully supports the UN-led inter-communal negotiations as the rightful venue to achieve a fair settlement.

[35] On 2 September 2020, United States decided to lift embargo on selling "non-lethal" military goods to Cyprus for one year starting from 1 October.

[36] On October 1, 2022, the United States formally lifted the Defense Trade Restrictions, allowing Cyprus to acquire American weapons.

Following the Annan Plan, the U.S. devoted an additional funding to assist the economic development of the Turkish Cypriots, in order to reduce future settlement costs.