[1][2][3] He was born in Constantinople, then part of the Ottoman Empire, where his father, Sir Peter Wyche, was the English Ambassador.

[1] Wyche was educated at Westminster School and Christ Church, Oxford, receiving a Bachelor of Arts in 1653.

[2] In 1660, around the time of the Stuart Restoration, he was knighted by Charles II in The Hague, likely owing to the influence of his brother-in-law, the Earl of Bath.

His administrative abilities were highly valued by both lords lieutenant and Essex described Wyche as "a very discreet understanding man".

[1] He continued to contribute to parliamentary sessions in England during this period and was commissioned to examine Edward Colman in Newgate Prison during the Popish Plot in 1678.

[2] Wyche declined to stand for re-election 1679, but two years later he was elected to represent East Grinstead on the interest of the Earl of Dorset.

Despite his shock at the new king's ostentatious attendance at Roman Catholic mass, he continued to be a court supporter in parliamentary proceedings.

[1] He remained out of crown employment until June 1700, when he was made chairman of the trustees for the Irish forfeitures, and returned to Ireland until 1703.