She released her second album, Aleik Ayouni in 2006, with debut single "Law Bas Fe Aini" (If he looks in my eyes) becoming one of the most popular Egyptian songs of the year.

[9][10] In 2003, she starred in the Arabic series Dareb Khwet as Ebanati, winning the 2003 Murex d'Or award for best Lebanese actress for the role.

Her third album with her record label (Rotana) was released in 2009, titled Layali El Hob (Nights of Love).

[17] In 2019, Cyrine starred in "Al-Hayba - The Harvest" (Arabic: الهيبة الحصاد) with the Syrian actor Taim Hassan and the TV series was a huge success.

She then starred with Lebanese actor Adel Karam in a 15 episode TV series named "Dor El Omor [1]" (Arabic: دور العمر) where she is a mentally ill young woman with a painful past.

[19] In 2015, after being attacked by many cyber trolls for celebrating Easter of that year, she defended her religious beliefs during an interview with Al Ghad Radio.