Saints Cyrus and John (Italian: Ciro e Giovanni; Arabic: أباكير ويوحنا, romanized: Abākīr wa-Yūḥannā; died c. 304 or 311 AD[1][2]) are venerated as martyrs.

[3] Cyrus practised the art of medicine, and had a workshop (ergasterium) which was afterwards transformed into a temple (church) dedicated to Shadrach, Meshach, and Abednego.

Cyrus and John, fearing lest these girls, on account of their youth, might, in the midst of torments, deny the Faith, resolved to go into the city to comfort them and encourage them in undergoing martyrdom.

At the time of St. Cyril, Patriarch of Alexandria (412–444), there existed at Menuthis (Menouthes or Menouthis) near Canopus and present-day Abu Qir, a pagan temple reputed for its oracles and cures which attracted even some simple Christians of the vicinity.

[5] In the fifth century, during the pontificate of Pope Innocent I, their relics were brought to Rome by two monks, Grimaldus and Arnulfus—this according to a manuscript in the archives of the deaconry of Santa Maria in Via Lata, cited by Antonio Bosio.

[6] Cardinal Angelo Mai, however, for historical reasons, justly assigns a later date, namely 634, under Pope Honorius I and the Emperor Heraclius (Spicilegium Rom., III, V).