The hepatobiliary triangle is the area bounded by the: It is covered in peritoneum both anteriorly and posteriorly.

[2] The anatomy and variant anatomy of this region is important during gallbladder removal to prevent iatrogenic injury to the common hepatic duct, bile duct, or right hepatic artery.

[3] The cystic artery lies within the hepatobiliary triangle, which is used to locate it during a laparoscopic cholecystectomy.

As a result, dissection in the triangle of Calot is ill-advised until the lateral-most structures have been cleared and identification of the cystic duct is definitive.

[6][7] Calot's original description of the triangle in 1890 included the cystic duct, the common hepatic duct, and the cystic artery (not the inferior border of the liver as is commonly believed).