[1] Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, including 15-40% of those with AIDS.

[7] Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions,[9] CMV infects around 40% of the population worldwide.

[10] Those areas infected by cytomegalovirus have cells evolve to necrosis, though inflammation within the retina is not great.

[13] The diagnosis of CMV retinitis can be done via the following:[7][14] In terms of the treatment of cytomegalovirus retinitis, oral valganciclovir, intravenous ganciclovir, IV foscarnet, and IV cidofovir are all efficient in the treatment of this condition.

Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil endotamponade.