Vrabel began his political career in 2021, running on the anti-vaccination "Open Czechia to Normal Life" list in the 2021 Czech parliamentary election.

[1] After the start of the Russian invasion of Ukraine, Vrabel organized a series of protests against the Fiala Cabinet, and wrote a manifesto entitled "Plan Czech Republic in First Place".

He also called on Czech President Miloš Zeman to dismiss Fiala's cabinet and name a government consisting of "experts" nominated by him.

[8] In late 2023, he founded Czech Republic in First Place!, seeking to run in the 2024 European elections.

When a reporter presented him with a poll suggesting that 60% of Czechs would vote to remain in the EU, Vrabel said he still believed "that the majority of people want to leave".