He played in Major League Baseball (MLB) for the New York Yankees, San Diego Padres, Chicago White Sox, Cincinnati Reds, Texas Rangers, Oakland Athletics, and Washington Nationals.

He had been considered one of the Yankees' top prospects, but in early 2000 Jiménez injured his back in a car crash that required him to miss the 2000 season.

On July 19, 2007, Jimenez was called as a pinch hitter and drove in the game-winning single after being in a horrible slump batting .040.

Later in the year he played for the Newark Bears of the Atlantic League On June 19, 2010, he signed with the Minnesota Twins and was assigned to the Rochester Red Wings.

On February 5, 2024, Jiménez was hired by the Chicago Cubs to serve as the bench coach for the team's Single–A affiliate, the Myrtle Beach Pelicans.