Wretzky was born and grew up in South Haven, Michigan where her mother, Vikke Anderson, a working musician, encouraged D'arcy and her sisters to perform music.

Wretzky accepted, and Jimmy Chamberlin completed the lineup a few months later, after Joe Shanahan encouraged Corgan to add a live drummer.

Wretzky is the credited bassist on the Smashing Pumpkins' first five studio albums: Gish, Siamese Dream, Mellon Collie and the Infinite Sadness, Adore, and Machina/The Machines of God.

[12] In the aftermath of the success of 1995's Mellon Collie and the Infinite Sadness, Corgan said that she began an "apparent slow descent into insanity and/or drugs (take your pick).

tour in April 1999 with all four original members performing together for the first time since 1996, Wretzky decided to leave the band and intended to pursue an acting career.

The band was recording Machina/The Machines of God and Machina II/The Friends and Enemies of Modern Music at the time and as a result she performed very few bass parts on the album.

In 2008, she and her former boyfriend and bandmate James Iha filed a lawsuit against Virgin Records for selling ringtones of Smashing Pumpkins songs without their consent.

[17] During the interview, she expressed that she was not healthy enough to be a musician, and repeatedly professed her admiration for Monkees frontman Davy Jones, who was known to be an early romantic crush of hers.

She also discussed her appreciation for the band Silversun Pickups, who have a sound influenced by the early Gish era of the Smashing Pumpkins.

[17] Wretzky was jailed on February 1, 2011, for missing four court dates related to a ticket she received for failing to control her wild horses, allowing them to freely roam the streets at night causing interference to local traffic and farmers, as well as trespassing on public property and stealing vegetables from the local farmer's market storage.

[19] On February 7, 2011, the day after she was released from jail, she was arrested again, this time on a misdemeanor drunken-driving road rage charge in South Haven, Michigan.

[25] Corgan released a statement denying the claims, writing that "Ms. Wretzky has repeatedly been invited out to play with the group, participate in demo sessions, or at the very least, meet face-to-face, and in each and every instance she always deferred.

In a 2016 interview with Loudwire, Filter lead singer Richard Patrick spoke of a romantic relationship which he had with Wretzky, saying that she was the subject of a song he wrote called "Miss Blue", also on Title of Record.