The lineup of Hizumi on vocals, Karyu on guitar, Zero on bass and Tsukasa on drums remained the same, with the group having released four full-length records, three EPs and thirteen singles.

They performed at the Wacken Open Air festival in 2006, to several thousand people,[4] and a second album, titled Mirror was released on April 11, 2007.

In the summer of 2010, the band had a world tour entitled Human-Clad Monsters in which they performed in Japan, the US, Canada and Europe.

After the last show of the tour, on December 30, the band went on an indefinite hiatus so Hizumi could recover from a rare throat condition.

[6] However, on June 15, 2011, D'espairsRay announced that they had no choice but to disband, due to Hizumi's health having no recovery in sight.

In January 2003, they gave out a "secret CD" titled tanji, with an unnamed song, to the people who attended one of their live shows.

It contained two previously released songs, "Fuyuu Shita Risou" and "Garnet", which were not on the initial limited edition of the album.

On May 4, 2008, they performed at the hide memorial summit at Ajinomoto Stadium, along with bands such as X Japan, Luna Sea, Maximum the Hormone and Marbell.

During the same month, D'espairsRay also announced a new album titled Redeemer, through Delicious Deli Records, a label under Universal Music Japan.

At an instore event during this month, Karyu and Zero briefly and ambiguously told fans that the single would be "dance style".

Just five days after the album was out, D'espairsRay began their "Human-Clad Monsters World Tour" starting in Los Angeles, California on August 3.

The band mentioned that the first half of the year was to be focused on Hizumi's recovering, and it was said that Karyu would be writing songs during this time.

The album features 17 B-Sides, the limited edition contained a DVD with every music video the band has made, from "Garnet" to "Death Point".

On June 15, 2011, it was announced that due to Hizumi's health having no recovery in sight, D'espairsRay had no choice but to disband.

[7] The band posted the following note on their official Facebook page on Wednesday, June 15, 2011, at 5:02 am: Thank you for your continued support of D'espairsRay.

To our loving fans and supportive staff members, who have followed us diligently from our founding on 9 Sept. 1999 until now, we deeply apologize for such a sudden and troubling announcement.

[16] Karyu joined Angelo in August 2011, which includes Kirito, Kohta, Takeo (all three ex:Pierrot) and Giru (ex:Vidoll).

[18] On August 24, 2011, Zero and Tsukasa formed The Micro Head 4N's with Kazuya and Shun (both ex:Fanatic Crisis), and Ricky (Dasein).

[23] D'espairsRay reunited for a performance at Angelo's The Intersection of Dogma event on July 29, 2014, at Zepp Diver City, which also featured Rize, lynch.