[3] The main local editions are for Toulouse, Ariège, Aude, Aveyron, Haute-Garonne, Gers, Lot, Lot-et-Garonne, Hautes-Pyrénées, Tarn and Tarn-et-Garonne.

[4][5] Publication was prompted by workers at the Sirven print works in Toulouse, which established the paper's left-leaning politics.

[5] It was at La Dépêche that the Socialist politician Jean Jaurès wrote his first articles.

Like other newspapers that had collaborated during the war, La Dépêche de Toulouse was closed by the postwar government in 1944.

[6] The combined circulation for the 17 regional dailies under La Dépêche du Midi was 200,000 copies in 2006.