[1] The station is defined by Deutsche Bahn as a Haltepunkt (roughly "halt") as it is not a junction and has no crossovers.

In 1877, the Rhenish Railway Company opened its Düsseldorf station at the modern Franklinbrücke (Franklin Bridge) just a few metres west of the modern Düsseldorf Zoo station.

The current Düsseldorf Zoo station was opened beneath Franklinbrücke in 1969 with the launch of the network of Rhine-Ruhr S-Bahn.

[4] Its current name commemorates the Düsseldorf Zoological Garden, which was located nearby to the north east between 1876 and 1943, when it was destroyed in an air raid.

Crossing over the railway tracks is a tram line, which connects with the trains at the station.