Led by Mufti Jafar Hussain, the protesters took over the nearby Pakistan Secretariat building, after which their demands were accepted, and they were exempted from paying the new proposed taxes.

A few months later, on 16 July 1993, Benazir Bhutto, who was the Leader of the Opposition then, led her supporters towards the Secretariat while pressuring Prime Minister Nawaz Sharif to resign.

This led to him, as well as President Ghulam Ishaq Khan, resigning, after the intervention of Chief of Army Staff Abdul Waheed Kakar.

[10] In April 2014, human rights activists and civil society members protested against missing persons at D-Chowk before being baton charge by the police.

[12][7] On 27 March 2016, thousands of protestors from religious groups camped out at D-Chowk for several days after observing the chelum of Mumtaz Qadri.

[13] In February 2022, Pakistan People's Party chairman Bilawal Bhutto Zardari led his Awami March, which commenced from Karachi and ended at Islamabad's D-Chowk.