D. S. Senanayake College (Sinhala: ඩී.ඇස්.සේනානායක විද්‍යාලය; Tamil: டி.எஸ் சேனாநாயக்க கல்லூரி; also referred to as DS and DSSC) is a boys' primary and secondary national school in Cinnamon Gardens, Colombo, Western Province, Sri Lanka.

It was established on 10 February 1967 with R. I. T. Alles as the founding principal,[1][2] and was named after the first Prime Minister of Sri Lanka, D. S. Senanayake.

Thus the Minister of Education I. M. R. A. Iriyagolla took the initiative to build a new school in Cinnamon Gardens on the lines of Royal College, Colombo.

The secretary of the Ministry of Education and Cultural Affairs, M. J. Perera, was assigned to find a suitable plot of land to start the new school.

Accordingly, the empty plot of land situated down the Gregory's road normally "Kubi Kelle" adjoining Kinsy road was selected for the purpose with another land bounded the said premises which belonged to the Ministry of Defense and also was acquired building plans were prepared and implemented by the state engineering co - operation.