The series attempts to re-imagine and pay homage to the era of culture and political turmoil which ushered in the presidency of John F. Kennedy.

Before he dies fighting a Tyrannosaurus rex, Johnny Cloud etches a final message in a cave wall, warning those who would find it that the island is "a living thing".

After the end of World War II, McCarthyism forces various Golden Age superheroes including the Justice Society of America into retirement, exile or branded as criminals.

In 1955, Martian J'onn J'onzz is accidentally transported to Earth by scientist Dr. Erdel, who suffers a fatal heart attack upon seeing the alien.

Using his telepathic and shapeshifting abilities, J'onzz takes the identity of Gotham City Detective John Jones, living as an honest cop while studying humanity's present knowledge of Martians.

In 1956, Barry Allen is struck by lightning and splashed with chemicals which grant him super speed, turning him into the superhero known as The Flash.

Hal goes through various grueling tests before being accepted by King Faraday to join a NASA expedition to Mars, a response to detection of Jones's arrival to Earth.

Using the medallion to unlock the cult's book, Jones discovers to his horror the presence of an alien entity known as "The Centre", which is pulling humanity's psyche into its thrall.

Jones later discovers from a rogue NASA scientist that a rocket to Mars is being constructed, and is tempted to return home after witnessing humanity's fear and hate towards different races.

Themyscira is soon attacked by the Centre, now revealed to be the island that Johnny Cloud had claimed to be sentient, in its path towards the American east coast.

A heavily injured Wonder Woman flies in her invisible jet to warn of the attack just as Superman had finished dispatching a scout from the Centre.

Lois Lane unveils the Centre to the world in a broadcast, prompting many to gather in an attempt to help defeat the creature, including Green Arrow, Adam Strange, Ray Palmer, the Blackhawks, the Sea Devils and Barry Allen who comes out of retirement.

Initially disheartened, the group formulate a plan to destroy the center using a nuclear payload and Ray Palmer's white dwarf lens.

Jones is overwhelmed by the psychic attack from the Centre and briefly falls under its control, but Faraday sacrifices himself by absorbing the mental strain and is killed.

The book ends with a montage of a new age of heroes narrated with the eponymous "New Frontier" speech by John F. Kennedy, as well as the formation of the Justice League of America as it battles Starro the Conqueror.