The main cities linked by the DN2 are: Bucharest, Buzău, Focșani, Bacău, Roman, and Suceava.

Together with the adjacent section of DN28, Săbăoani – Iași, part of E583, the DN2 is currently Moldavia's backbone.

[citation needed] The DN2 is also considered Romania's most dangerous trunk road.

The road has high accident rates, and the Bucharest–Săbăoani section is the most affected, due to drivers improperly using the emergency lanes.

This upgrade was made in 2019, and due to the resulting low accident rates, it has been demanded that the rest of DN2 between Bucharest and Săbăoani, as well as DN28 to Iași be converted to a 2+1 road also.