[5] It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G-proteins.

However, Dock6 has been reported to exhibit dual GEF specificity towards the small G proteins Rac1 and Cdc42.

[10] It is the only DOCK family member reported to activate both of these G proteins.

The same study also showed that transfection of the Dock6 DHR2 domain into N1E-115 neuroblastoma cells promoted Rac- and Cdc42-dependent neurite outgrowth, although the physiological significance of this has yet to be demonstrated.

This article on a gene on human chromosome 19 is a stub.