In the first government of Chancellor Angela Merkel between 2005 and 2009, she served as Parliamentary State Secretary in the Federal Ministry of Economics and Technology under ministers Michael Glos (2005–2009) and Karl-Theodor zu Guttenberg (2009).

In the negotiations to form a coalition government following the 2009 federal elections, Wöhrl was part of the CDU/CSU delegation in the working group on economic affairs and energy policy, led by Guttenberg and Rainer Brüderle.

In addition, she joined the delegations of Federal Minister of Economic Cooperation and Development Gerd Müller to Nigeria (2014), Ghana (2015), Liberia (2015) and the Central African Republic (2015).

"[4] During her time in parliament, Wöhrl voted in favor of German participation in United Nations peacekeeping missions as well as in United Nations-mandated European Union peacekeeping missions on the African continent, such as in Somalia – both Operation Atalanta and EUTM Somalia – (2009, 2010, 2012, 2013, 2014 and 2015), Darfur/Sudan (2010, 2011, 2012, 2013, 2014 and 2015), South Sudan (2011, 2012, 2013, 2014 and 2015), Mali – both EUTM Mali and MINUSMA – (2013, 2014, 2015 and 2016), the Central African Republic (2014), and Liberia (2015).

[6] By early 2017, media reported that Wöhrl would be joining the jury of Die Höhle der Löwen, a VOX reality television format featuring entrepreneurs pitching their business ideas in order to secure investment finance from a panel of venture capitalists.