[9] After appearing in the 2016 Outnumbered Christmas Special on BBC One, at 17, Edgar-Jones was cast as Olivia Marsden in ITV's comedy drama Cold Feet alongside James Nesbitt.

[10] In 2018, she appeared as Jessica Timpson in Silent Witness,[11] and in independent coming-of-age feature film Pond Life, directed by Bill Buckhurst.

She played Emily Gresham for the first two seasons of War of the Worlds opposite Gabriel Byrne and Elizabeth McGovern.

[15] In May 2019, it was announced that Edgar-Jones had been cast in the main role of Marianne alongside Paul Mescal as Connell in the Hulu and BBC Three series Normal People, an adaptation of the novel by Sally Rooney.

[16][17] Edgar-Jones starred in the February 2020 revival of Albion at the Almeida Theatre,[18] which was recorded and later broadcast by the BBC that August.