The following season, Weise improved to 43 points (18 goals and 25 assists) over 67 games, ranking second in team scoring, behind centre Levi Nelson.

[1] He then recorded one assist in six playoff games as the Broncos were eliminated in the first round for the second consecutive year, this time by the Regina Pats.

Weise played his last season with the Broncos in 2007–08 and recorded a WHL career-high 51 points (29 goals and 22 assists) over 53 games, ranking fifth in team scoring.

[5] The following week, he was assigned to the Rangers' American Hockey League (AHL) affiliate, the Hartford Wolf Pack[5] and made his professional debut on October 11, 2008, against the Springfield Falcons.

[7] Near the end of the regular season, Weise was named the Wolf Pack's American Specialty/AHL Man of the Year for his community service contributions in the Hartford, Connecticut, area.

The honour made him a nominee for the League's Yanick Dupre Memorial Award for community service,[8] which went to Brandon Rogers of the Houston Aeros.

Attending his second Rangers training camp in September 2009, Weise was once again assigned to the Wolf Pack for the start of the 2009–10 season.

[20][21] Weise's place on the Canucks' roster helped stabilize the team's fourth line, which had gone through 14 different players the previous year.

[22][23] On January 18, 2014 Weise was involved in an infamous line brawl that had him square off against Calgary Flames forward Blair Jones, one of several fights to break out.

[28] On February 26, 2016, with the club on the outside of playoff contention, Weise was traded to the Chicago Blackhawks along with teammate Tomas Fleischmann in exchange for a 2018 second round draft pick and Phillip Danault.

In the 2018–19 season, on January 27, 2019, despite contributing with 11 points in 42 games, the Flyers placed Weise on waivers and assigned him to their American Hockey League affiliate, the Lehigh Valley Phantoms.

[33] On February 9, 2019, Weise returned to the Canadiens' organization when he and Christian Folin were traded in exchange for David Schlemko and Byron Froese.

[34] Two days later, on February 11, 2019, Weise was recalled to the Canadiens[35] when a roster spot was made available after Kenny Agostino was claimed off waivers by the New Jersey Devils.