He took an important step toward his vision of making art more accessible in 1821, when he established a school for artists in his residence in Tondo.

The academy was also possibly the first of its kind in all of Asia to teach the Western techniques of foreground, middle-ground, and background perspectives.

[2] His term as director saw the introduction of non-discriminatory policies that conferred equal rights on the Indios, who until then had been mostly marginalized.

[2] To date, few works by Domingo survive today with three full albums of the tipos del pais are known to exist with two held in two prominent private collections in the Philippines, while a fully signed album dated between 1827 and 1832 by Domingo previously in the collection of American businessman Edward E. Ayer that was subsequently donated to the Newberry Library.

[4] In 2019, an undated yet signed work by Domingo from the tipos del pais series previously from a private collection in the United States: Un Indio Noble de Manila sold for a record PHP3.74 million (US$71,824.44) at Leon Gallery in the Philippines, becoming the most expensive artwork sold by the artist internationally.