Under Manuel I’s successor, King John III of Portugal, in 1523, he was sent to Antwerp, as secretary and treasurer of the Portuguese feitoria (factory, trading post and commercial office).

Henceforth, Góis travelled intensely (Poland, Lithuania, Denmark, Germany, Sweden, France, England, Italy), entering into contact with a number of important figures, like Sebastian Münster, Erasmus (who hosted him in Freiburg), Giovanni Battista Ramusio, Philipp Melanchthon, Thomas More and Martin Luther.

A humanist and an open mind, Góis followed courses at the Universities of Padua and Leuven, wrote on various topics, like the condition of the Sami people ("Lapps"), and translated some classic works – among them, Cicero’s Cato maior de senectute – into Portuguese.

He was rewarded, however, by a grant of arms from Charles V. He finally returned to Portugal in 1545, with a view of becoming tutor to the king's son, but he failed to obtain this post, owing to the accusations before the Inquisition.

[4] In 1548, Góis was named Guarda-Mor (High Guardian) of the Torre do Tombo (Royal Archives) and ten years later was entrusted by the same Cardinal Henry to write the chronicle of Manuel I’s reign.

He died shortly after in Alenquer under mysterious circumstances (apparently, murder), free but sick, and was buried in the church of Nossa Senhora da Várzea.