He played quarterback and earned all-state honors while passing for 46 touchdowns and compiling 5,743 yards of total offense.

As of 2010[update] Enos has the third-best all-time pass completion percentage in Spartan history (.621) and eighth-best total yards (4,301).

In 1994 Enos joined the coaching staff at Lakeland College, a Division III school in Sheboygan, Wisconsin.

As offensive coordinator, Enos helped develop Mark Novara, Lakeland's most successful quarterback.

In 1999, Enos was announced to his first Division I offensive coordinator position at Missouri State in 1999 under then-head coach Randy Ball.

In 2003, Enos was hired as the offensive coordinator at Division I-FCS North Dakota State University.

The following Wednesday the student newspaper, Central Michigan Life, published an editorial calling for Enos to be fired.

Enos was again rewarded with a one-year contract extension and pay raise in January 2013, extending his deal through the 2016 season.

Enos also coached Hunter Henry in 2015 who won the John Mackey Award as the nation's best tight end.

Enos was widely credited with Alabama quarterback Tua Tagovailoa's high completion percentage and passer efficiency rating for the 2018 season.

On December 26, 2019, after a 14–0 shutout loss to Louisiana Tech in the Independence Bowl, Miami parted ways with Enos.

[20] On October 22, 2023, the University of Arkansas announced Enos had been relieved of his coaching duties following a 7–3 loss at home to Mississippi State.