His other screenwriting credits include Freejack (1992), Two for the Money (2005), The Fall (2006), Real Steel (2011), and The Bourne Legacy (2012)—the last in collaboration with his brother Tony Gilroy.

It tells the story of an NSA satellite analyst who discovers a sunken Russian submarine off the coast of California containing the remains of American sailors.

"[14][15] Gilroy began his screenwriting career by co-writing the science fiction thriller Freejack (1992) with Steven Pressfield and Ronald Shusett, directed by Geoff Murphy and based on the novel Immortality, Inc. by Robert Sheckley.

[16] In his positive review of Two for the Money, Roger Ebert of the Chicago Sun-Times said Gilroy's script "is about three people who are transformed in relation to one another, as a situation develops that is equally dangerous all the way around".

[18] Manohla Dargis of The New York Times described the Gilroys' script as something that "has given [Tony] much more to wrangle—locations, characters, hardware, franchise expectations—than he's had to deal with in the past",[19] while Toronto Star reviewer Peter Howell said it resorted "too much into jabbering and jargon and not enough into action".

[22] Gilroy did not begin writing the script until he moved to Los Angeles two years later, when he recognized an abundance of violent stories on television news.

[26] In 2017, he co-wrote Jordan Vogt-Roberts's adventure Kong: Skull Island with Max Borenstein and Derek Connolly,[27] and wrote and directed Roman J. Israel, Esq., a legal drama starring Denzel Washington.

[35] Gilroy was hired by Tim Burton to re-write Wesley Strick's Superman Lives script, making it more budget conscious and expanding the psychology for the final shooting drafts before it was cancelled by WB.