Heder has had starring roles in the comedy films The Benchwarmers (2006), School for Scoundrels (2006), Blades of Glory (2007), Mama's Boy (2007), When in Rome (2010), Reality (2014), and Ghost Team (2016).

[7] A 2002 alumnus of Brigham Young University, Heder worked on the short animated film Pet Shop.

Also in 2006, Heder was the voice of the character Skull in the animated film Monster House, and starred in the comedy School for Scoundrels, opposite Billy Bob Thornton and Jacinda Barrett.

He co-starred in 2007 with Will Ferrell in the well-received Blades of Glory (2007) where, as in many of his films, he plays an absurd, slapstick caricature—this time, one of two rival figure skaters who must team up in a pairs competition.

The live-action, sci-fi comedy thriller follows Drex, a USC student who wakes up underwater in the bathtub one morning and suspects he may be dead.

[12] Heder and his twin brother, Dan, star together as villains in the fourth installment of the popular internet martial arts comedy series Sockbaby.

Heder served a mission for The Church of Jesus Christ of Latter-day Saints in Japan, and speaks Japanese fluently.