In 1988, incumbent vice president and Republican presidential nominee George H. W. Bush chose Quayle as his running mate.

During his tenure, Quayle made official visits to 47 countries and was appointed chairman of the National Space Council.

[1][2][3][4] He secured re-nomination for vice president in 1992, but was defeated by the Democratic ticket of Bill Clinton and Al Gore.

He sought the Republican presidential nomination in 2000 but withdrew his campaign early on and supported the eventual nominee, George W. Bush.

degree in political science in 1969,[9] was the captain of the university golf team and a member of the fraternity Delta Kappa Epsilon (Psi Phi chapter).

[13][14] At Indiana University, he met his future wife, Marilyn, who was taking night classes at the same law school at the time.

After graduating from law school in 1974, Quayle worked as associate publisher of his family's newspaper, the Huntington Herald-Press.

In 1976, Quayle was elected to the House of Representatives from Indiana's 4th congressional district, defeating eight-term incumbent Democrat J. Edward Roush by a 55%-to-45% margin.

The decision likely saved Quayle's life, because Ryan and his entourage were subsequently murdered at the airstrip in Jonestown as the party tried to escape the massacre.

[18] In 1980, at age 33, Quayle became the youngest person ever elected to the Senate from the state of Indiana, defeating three-term incumbent Democrat Birch Bayh with 54% of the vote.

[19] Manion was nominated for the Seventh Circuit of the U.S. Court of Appeals by President Ronald Reagan on February 21, 1986, and confirmed by the Senate on June 26, 1986.

On August 16, 1988, at the Republican convention in New Orleans, Louisiana, George H. W. Bush chose Quayle to be his running mate in the 1988 United States presidential election.

[23] The questions involved his military service, a golf holiday in Florida where he and several other politicians shared a house with lobbyist Paula Parkinson,[24][12] and whether he had enough experience to be vice president.

[21][23][25] Although Bush was trailing by up to 15 points in public opinion polls taken before the convention, in August the Bush–Quayle ticket took the lead,[26] which it did not relinquish for the rest of the campaign.

[27] The Bush–Quayle ticket won the November election by a 53–46 percent margin, sweeping 40 states and capturing 426 electoral votes.

Quayle cast no tie-breaking votes as president of the Senate, becoming only the second vice-president (after Charles W. Fairbanks) not to do so while serving a complete term.

As head of the NSC he called for greater efforts to protect Earth against the danger of potential asteroid impacts.

), Max Hunter, and Jerry Pournelle, Quayle sponsored the development of an experimental Single Stage to Orbit X-Program, which resulted in the building of the McDonnell Douglas DC-X.

[29] On May 19, 1992, Quayle gave a speech titled Reflections on Urban America to the Commonwealth Club of California on the subject of the Los Angeles riots.

[30] In an aside, he cited the single mother title character in the television program Murphy Brown as an example of how popular culture contributes to this "poverty of values", saying, "It doesn't help matters when prime-time TV has Murphy Brown—a character who supposedly epitomizes today's intelligent, highly paid, professional woman—mocking the importance of fathers, by bearing a child alone, and calling it just another 'lifestyle choice'.

Others interpreted it differently; singer Tanya Tucker was widely quoted as saying "Who the hell is Dan Quayle to come after single mothers?

Contributing to this perception of Quayle was his tendency to make public statements that were either impossible ("I have made good judgments in the past.

Quayle said he was uncomfortable with the version he gave, but did so because he decided to trust the school's incorrect written materials instead of his own judgment.

Quayle's second book, The American Family: Discovering the Values That Make Us Strong, was co-authored with Diane Medved and published in 1996.

[48] On April 14, 1999, at a rally held at his alma mater Huntington North High School's gymnasium, Quayle officially launched his campaign for the 2000 Republican presidential nomination.

[50] Quayle, then working as an investment banker in Phoenix, was mentioned as a candidate for governor of Arizona before the 2002 election,[53] but declined to run.

On January 31, 2011, Quayle wrote a letter to President Barack Obama urging him to commute Jonathan Pollard's sentence.

[59] He has also been on the boards of directors of other companies, including K2 Sports, AmTran Inc., Central Newspapers Inc.,[60] BTC Inc.[61] and Carvana Co.[62] According to the book Peril, by Bob Woodward and Robert Costa, Quayle played a central role in advising his fellow Hoosier and Vice President Mike Pence to certify the 2020 United States presidential election as per the Senate rules, rather than cooperate with a plan by then-president Donald Trump that sought to overturn the election.

In 1999, Quayle joined Cerberus Capital Management, a multibillion-dollar private-equity firm, where he serves as chair of the company's Global Investments division.

[76] In September 1992, Quayle acknowledged that joining the Indiana National Guard cut his risks of being deployed to Vietnam, although he defended his decision.